Most of us who need to raise support use e-mail for a lot of our communications. I have used a few different products to try to handle sending bulk HTML e-mails to financial and prayer supporters but I have not really found one that I am fully happy with. At the moment I am trying Microsoft Outlook with Business Contact Manager, which seems to be pretty good so far, but it does not offer a way to track if people are reading the e-mails, or clicking on the links.
MailChimp, which is an on-line e-mail list management service from what I can tell, is offering a free e-book about managing online e-mail campaigns and designing and coding HTML e-mails. I am about to download it to have a look, but thought I would link to the free book for others to check out if you want to: